Malaria vaccine
Identifieur interne : 002F67 ( Main/Exploration ); précédent : 002F66; suivant : 002F68Malaria vaccine
Auteurs : U. Certa [Suisse]Source :
- Experientia [ 0014-4754 ] ; 1991-02-01.
English descriptors
- KwdEn :
- Teeft :
- Amino acids, Animal model, Antibody attack, Antigen, Antigen variation, Aotus, Aotus monkeys, Best protection, Biological sense, Blood cells, Blood stream, Certain epitopes, Complete protection, Control group, Crossover events, Cultured parasites, Current spread, Diploid stage, Disease agents, Endemic areas, Epitope, Experientia, Falciparum, Falciparum infection, Full protection, Gametocyte, Gene encoding, Gene sequences, Genetic level, Greatest killer, High degree, Human volunteers, Immun, Immune, Immune response, Immune system, Immunization, Infectious diseases, Intensive research, Large amounts, Large number, Last decade, Life cycle, Major surface antigens, Major surface protein, Malaria, Malaria parasites, Malaria symptoms, Merozoite, Molecular biology, Monoclonal antibodies, Mosquito, Natl acad, Other antigens, Parasite, Parasite biology, Parasite cultures, Parasitemia, Partial immunity, Particular parasite, Plasmodium, Plasmodium falciparum, Plasmodium faleiparum, Plasmodiumfalciparum, Plasmodiumfalciparum malaria, Primary infection, Protective immunity, Recombinant, Recombinant protein, Recombinant proteins, Relapsing fever, Repetitive, Repetitive epitopes, Reviews experientia, Sporozoite, Sterile immunity, Subtropical countries, Surface glycoprotein, Synthetic peptides, Synthetic vaccine, Urgent need, Vaccination, Vaccine, Vaccine development.
Abstract
Summary: Among infectious diseases caused by protozoa, malaria is still the greatest killer of children. Mortality in adults living in endemic areas is significantly lower because they frequently acquire partial or complete immunity to the major pathogen,Plasmodium falciparum. This natural protection indicates that vaccination may be possible, and the first candidate antigens were cloned with the use of human immune sera as probes. Genetic and biochemical analysis of the parasite proteins revealed that they are polymorphic, and frequently gene sequences were discovered which were specific for a particular parasite isolate, which eliminated most antigens for purposes of vaccine development. The most promising candidate antigens today are the major surface proteins of sporozoites and blood stage parasites. However, the immune response against those is not sufficient for complete protection, and additional, intensive research is necessary to identify new molecules to be included in a vaccine cocktail against malaria. The current spread of the disease due to increasing drug resistance of parasites and mosquito vectors emphasizes the urgent need for a vaccine.
Url:
DOI: 10.1007/BF01945417
Affiliations:
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Le document en format XML
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Certa</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Central Research Units, Hoffmann-La Roche Ltd., CH-4002, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Experientia</title><title level="j" type="abbrev">Experientia</title><idno type="ISSN">0014-4754</idno><idno type="eISSN">1420-9071</idno><imprint><publisher>Birkhäuser-Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="1991-02-01">1991-02-01</date><biblScope unit="volume">47</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="163">163</biblScope></imprint><idno type="ISSN">0014-4754</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4754</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Malaria vaccine</term><term>antigen polymorphism</term><term>recombinant DNA</term><term>surface proteins</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amino acids</term><term>Animal model</term><term>Antibody attack</term><term>Antigen</term><term>Antigen variation</term><term>Aotus</term><term>Aotus monkeys</term><term>Best protection</term><term>Biological sense</term><term>Blood cells</term><term>Blood stream</term><term>Certain epitopes</term><term>Complete protection</term><term>Control group</term><term>Crossover events</term><term>Cultured parasites</term><term>Current spread</term><term>Diploid stage</term><term>Disease agents</term><term>Endemic areas</term><term>Epitope</term><term>Experientia</term><term>Falciparum</term><term>Falciparum infection</term><term>Full protection</term><term>Gametocyte</term><term>Gene encoding</term><term>Gene sequences</term><term>Genetic level</term><term>Greatest killer</term><term>High degree</term><term>Human volunteers</term><term>Immun</term><term>Immune</term><term>Immune response</term><term>Immune system</term><term>Immunization</term><term>Infectious diseases</term><term>Intensive research</term><term>Large amounts</term><term>Large number</term><term>Last decade</term><term>Life cycle</term><term>Major surface antigens</term><term>Major surface protein</term><term>Malaria</term><term>Malaria parasites</term><term>Malaria symptoms</term><term>Merozoite</term><term>Molecular biology</term><term>Monoclonal antibodies</term><term>Mosquito</term><term>Natl acad</term><term>Other antigens</term><term>Parasite</term><term>Parasite biology</term><term>Parasite cultures</term><term>Parasitemia</term><term>Partial immunity</term><term>Particular parasite</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Plasmodium faleiparum</term><term>Plasmodiumfalciparum</term><term>Plasmodiumfalciparum malaria</term><term>Primary infection</term><term>Protective immunity</term><term>Recombinant</term><term>Recombinant protein</term><term>Recombinant proteins</term><term>Relapsing fever</term><term>Repetitive</term><term>Repetitive epitopes</term><term>Reviews experientia</term><term>Sporozoite</term><term>Sterile immunity</term><term>Subtropical countries</term><term>Surface glycoprotein</term><term>Synthetic peptides</term><term>Synthetic vaccine</term><term>Urgent need</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine development</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Among infectious diseases caused by protozoa, malaria is still the greatest killer of children. Mortality in adults living in endemic areas is significantly lower because they frequently acquire partial or complete immunity to the major pathogen,Plasmodium falciparum. This natural protection indicates that vaccination may be possible, and the first candidate antigens were cloned with the use of human immune sera as probes. Genetic and biochemical analysis of the parasite proteins revealed that they are polymorphic, and frequently gene sequences were discovered which were specific for a particular parasite isolate, which eliminated most antigens for purposes of vaccine development. The most promising candidate antigens today are the major surface proteins of sporozoites and blood stage parasites. However, the immune response against those is not sufficient for complete protection, and additional, intensive research is necessary to identify new molecules to be included in a vaccine cocktail against malaria. The current spread of the disease due to increasing drug resistance of parasites and mosquito vectors emphasizes the urgent need for a vaccine.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Certa, U" sort="Certa, U" uniqKey="Certa U" first="U." last="Certa">U. Certa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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